Palmitoylethanolamide
Palmitoylethanolamide (PEA) is an endogenously-produced lipid-like molecule that is very similar to endocannabinoids. PEA has anti-inflammatory properties and has been used to treat allergies, chronic pain, neurodegeneration, mental disorders, and sleep conditions.
Quick Answer
What it is
Palmitoylethanolamide (PEA) is an endogenously-produced lipid-like molecule that is very similar to endocannabinoids. PEA has anti-inflammatory properties and has been used to treat allergies, chronic pain, neurodegeneration, mental disorders, and sleep conditions.
Key findings
- Grade D: Pain (Primary Dysmenorrhea (Menstrual Cramps))
Safety
No specific caution or interaction language was detected in the current summary/outcome notes.
鈩癸笍 Quick Facts: Palmitoylethanolamide
Quick Facts: Palmitoylethanolamide
- Best Evidence:Grade D
- Conditions Studied:1
- Research Outcomes:1
- Key Effect:Primary Dysmenorrhea (Menstrual Cramps)
Detailed Outcomes
Evidence by Condition
Best grade per condition (each condition may have multiple outcomes)
Research Citations (1)
Related Supplements
Yarrow
1 shared condition 路 19 outcomes
The yarrow plant (Achillea millefolium) is a member of the Asteraceae family that has been used in cultural and traditional treatment of wounds, menstrual concerns, and gastrointestinal discomfort worldwide.
Vitamin E
1 shared condition 路 274 outcomes
Vitamin E is a fat-soluble antioxidant that protects cells from oxidative damage and is found in several common foods. Supplementing with extra vitamin E does not have broad health benefits, except in people with vitamin E deficiency, and long-term high-dose supplementation may cause harm.
Vitamin D
1 shared condition 路 308 outcomes
Vitamin D is a fat-soluble vitamin that our skin synthesizes when exposed to the sun. It benefits us in many ways, from bone health to mood.
Vitamin B6
1 shared condition 路 12 outcomes
Vitamin B6 is a water-soluble vitamin that is essential for health. After ingestion, it is converted into a coenzyme that supports the function of numerous enzymes in the body important for brain and cognitive development, immune function, and metabolic processes. Although deficiencies are rare, people on specific medications or with distinct medical conditions may require supplementation.
Valerian
1 shared condition 路 20 outcomes
Valeriana officinalis, also known as valerian, is an herb that can be taken as a tea or a supplement. It is commonly used for its sedative and anxiety-reducing effects.
Saffron
1 shared condition 路 390 outcomes
Saffron is a spice with antioxidant properties derived from the flowering plant Crocus sativus. When used as a supplement, saffron seems to be effective at reducing symptoms of depression and possibly anxiety.
Lemon Balm
1 shared condition 路 55 outcomes
Lemon balm (Melissa officinalis) is a bushy perennial herb in the mint family that has been used in food for over two thousand years. Oral ingestion of lemon balm may help reduce anxiety and depression and improve sleep. Supplementation with lemon balm can also improve blood lipids and blood pressure. When applied to the skin, lemon balm may help with cold sores.
Lavender
1 shared condition 路 57 outcomes
Lavender is a plant in the Lamiaceae (mint) family. It is an aromatic plant, and its essential oil is often used in aromatherapy for relief of stress and anxiety.