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N-Phenylacetyl-L-prolylglycine ethyl ester, better known as Noopept, is a lab-made compound related to the brain's own peptides, and it is thought to influence how nerve cells signal and adapt. People mostly look at it for mild problems with memory and thinking, and one small trial of 41 people with mild cognitive impairment found that rehabilitation after brain injury improved, though the evidence is limited. That study compared it with piracetam and came from a single research group, so there is too little research to say how well the result holds up.
Sources: PMID 19234797
- Updated
- How we grade
- 9 studies cited
- Best evidence
- Grade C
- Conditions studied
- 1
- Outcomes
- 1
- Graded outcomes
- 0010
Evidence by condition
- Strong
- Moderate
- Limited
- Very limited
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Cerebral Trauma Rehabilitation Moderate Improvement | Improves (the measure goes up) | Moderate effect | 1 study | 41 people | ||
Studies that measured cerebral trauma rehabilitation | ||||||
Key findings
- Cerebral Trauma RehabilitationImproves (the measure goes up)
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Third-party tested N-Phenylacetyl-L-prolylglycine ethyl ester products. The evidence above is limited, so read it before you buy.
- Grade C
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Studies cited
9 studies from PubMed
- Cognitive Enhancer Noopept Activates Transcription Factor HIF-1
- Drug with Neuroprotective Properties Noopept Does Not Stimulate Cell Proliferation
- Neuroprotective effect of novel cognitive enhancer noopept on AD-related cellular model involves the attenuation of apoptosis and tau hyperphosphorylation
- On the mechanism of noopept action: decrease in activity of stress-induced kinases and increase in expression of neutrophines
- Noopept stimulates the expression of NGF and BDNF in rat hippocampus
- The nootropic and neuroprotective proline-containing dipeptide noopept restores spatial memory and increases immunoreactivity to amyloid in an Alzheimer's disease model
- Noopept improves the spatial memory and stimulates prefibrillar beta-amyloid(25-35) antibody production in mice
- The original novel nootropic and neuroprotective agent noopept
- Comparative studies of Noopept and piracetam in the treatment of patients with mild cognitive disorders in organic brain diseases of vascular and traumatic origin