N-Phenylacetyl-L-prolylglycine ethyl ester

N-phenylacetyl-L-prolylglycine ethyl ester (brand name: Noopept), a Nootropic molecule similar to Piracetam that may alleviate cognitive decline.

Quick Answer

What it is

N-phenylacetyl-L-prolylglycine ethyl ester (brand name: Noopept), a Nootropic molecule similar to Piracetam that may alleviate cognitive decline.

Key findings

Grade C: Cerebral Trauma Rehabilitation (Mild Cognitive Impairment (MCI))

Safety

No specific caution or interaction language was detected in the current summary/outcome notes.

ℹ️ Quick Facts: N-Phenylacetyl-L-prolylglycine ethyl ester

Quick Facts: N-Phenylacetyl-L-prolylglycine ethyl ester

Best Evidence:Grade C
Conditions Studied:1
Research Outcomes:1
Key Effect:Mild Cognitive Impairment (MCI)

Outcomes by grade:

A0

B0

C1

D0

1 conditions · 1 outcomes

Detailed Outcomes

C

Cerebral Trauma Rehabilitation

Moderate Improvement

41 participants

moderate↑Improves

Evidence by Condition

Best grade per condition (each condition may have multiple outcomes)

CMild Cognitive Impairment (MCI)

1 outcome · 1 study

↑Cerebral Trauma RehabilitationImproves

Research Citations (9)

Cognitive Enhancer Noopept Activates Transcription Factor HIF-1

Dokl Biochem Biophys (2020)

Drug with Neuroprotective Properties Noopept Does Not Stimulate Cell Proliferation

Bull Exp Biol Med (2019)

Neuroprotective effect of novel cognitive enhancer noopept on AD-related cellular model involves the attenuation of apoptosis and tau hyperphosphorylation

J Biomed Sci (2014)

On the mechanism of noopept action: decrease in activity of stress-induced kinases and increase in expression of neutrophines

Eksp Klin Farmakol (2010)

Noopept stimulates the expression of NGF and BDNF in rat hippocampus

Bull Exp Biol Med (2008)

The nootropic and neuroprotective proline-containing dipeptide noopept restores spatial memory and increases immunoreactivity to amyloid in an Alzheimer's disease model

J Psychopharmacol (2007)

Noopept improves the spatial memory and stimulates prefibrillar beta-amyloid(25-35) antibody production in mice

Eksp Klin Farmakol (2005)

The original novel nootropic and neuroprotective agent noopept

Eksp Klin Farmakol (2002)

Comparative studies of Noopept and piracetam in the treatment of patients with mild cognitive disorders in organic brain diseases of vascular and traumatic origin

Neurosci Behav Physiol

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