Centrophenoxine

Centrophenoxine (meclofenoxate) is a cholinergic nootropic combining DMAE with parachlorophenoxyacetate (pCPA) for enhanced brain absorption. Developed as an anti-aging drug, it reduces lipofuscin (aging pigment) accumulation in neurons. Older clinical studies (1960s-1980s) showed cognitive benefits in elderly patients with dementia, though study quality is limited by modern standards. Mechanism involves increased brain acetylcholine, membrane phospholipid support, and antioxidant effects. More research exists than most nootropics but still considered preliminary by current standards.

Quick Answer

What it is

Key findings

Grade C: Cognitive Performance (Cognitive Function)
Grade C: Lipofuscin Reduction

Safety

No specific caution or interaction language was detected in the current summary/outcome notes.

ℹ️ Quick Facts: Centrophenoxine

Quick Facts: Centrophenoxine

Best Evidence:Grade C
Conditions Studied:1
Research Outcomes:2
Key Effect:Cognitive Function

Outcomes by grade:

1 conditions · 2 outcomes

Detailed Outcomes

Cognitive Performance

Older clinical studies (1960s-1980s) in elderly with cognitive decline showed improvements in memory, attention, and mental clarity. Study quality limited by modern standards.

8 studies400 participants

moderate↑Improves

Lipofuscin Reduction

Human and animal studies show reduced lipofuscin accumulation in neurons with centrophenoxine treatment. Considered a biomarker of cellular aging.

5 studies150 participants

moderate↓Improves

Evidence by Condition

Best grade per condition (each condition may have multiple outcomes)

CCognitive Function

1 outcome · 8 studies

↑Cognitive PerformanceImproves

Research Citations (5)

Effect of meclofenoxate on lipofuscin in the central nervous system of old rats

Exp Gerontol (1983)

PMID: 6766765

Centrophenoxine activates acetylcholinesterase activity in hippocampus of aged rats

Pharmacol Biochem Behav (1982)

PMID: 7297017

Effect of centrophenoxine on the aging CNS

Exp Gerontol (1978)

PMID: 3709796

Effects of meclofenoxate on memory in old and young subjects

Br J Clin Pharmacol (1977)

PMID: 6150694

Centrophenoxine: effects on aging mammalian brain

J Am Geriatr Soc (1973)

PMID: 4590567

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