Supplement
Centrophenoxine is a compound made from DMAE and a plant-growth-hormone-like acid, and it is thought to support the brain's cell membranes and neurotransmitter building blocks. People mostly look at it for cognitive function, and older studies in elderly people with cognitive decline found improvements in memory, attention, and mental clarity, though the evidence is limited. Those studies date from the 1960s to 1980s and fall short of modern quality standards, and work on lipofuscin, a cellular aging marker, came mostly from animal or lab studies.
- Updated
- How we grade
- 5 studies cited
- Best evidence
- Grade C
- Conditions studied
- 2
- Outcomes
- 2
- Graded outcomes
- 0020
Evidence by condition
- Strong
- Moderate
- Limited
- Very limited
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Cognitive Performance Older clinical studies (1960s-1980s) in elderly with cognitive decline showed improvements in memory, attention, and mental clarity. Study quality limited by modern standards. | Improves (the measure goes up) | Moderate effect | 400 people |
Aging And Longevity
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Lipofuscin Reduction Human and animal studies show reduced lipofuscin accumulation in neurons with centrophenoxine treatment. Considered a biomarker of cellular aging. | Improves (the measure goes down) | Moderate effect | 150 people |
Key findings
- Cognitive PerformanceImproves (the measure goes up)
- Lipofuscin ReductionImproves (the measure goes down)
Shop Centrophenoxine
Third-party tested Centrophenoxine products. The evidence above is limited, so read it before you buy.
- Grade C
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Studies cited
5 studies from PubMed
- Effect of meclofenoxate on lipofuscin in the central nervous system of old rats
- Centrophenoxine activates acetylcholinesterase activity in hippocampus of aged rats
- Effect of centrophenoxine on the aging CNS
- Effects of meclofenoxate on memory in old and young subjects
- Centrophenoxine: effects on aging mammalian brain