Protocol · Neurological
Mild Cognitive Impairment (MCI) Protocol
Omega-3 DHA and Phosphatidylserine are the core of this stack, with 2 supporting supplements. Each row gives the amount the protocol lists and the grade our evidence database holds for that supplement in Mild Cognitive Impairment (MCI).
We are re-verifying the studies cited on protocol pages; only confirmed citations are shown.
The stack
4 supplements · 2 graded · 2 confirmed studies
| Grade | Supplement | Amount listed | Why it’s in the stack | Evidence on file | Shop |
|---|---|---|---|---|---|
| Primary stackThe core of this protocol | |||||
| Omega-3 DHA | Amount listed: 1–2 g DHA daily | DHA is the primary structural fatty acid in brain cell membranes, supporting neuronal function and reducing neuroinflammation | Not graded yet | ||
| Phosphatidylserine | Amount listed: 100–300 mg daily | Essential phospholipid for neuronal membrane integrity and cell signaling, supports memory and cognitive function
| Grade C for Forgetting15 people | ||
| Supporting stackListed as additions to the core | |||||
| B Vitamins (B6, B12, Folate) | Amount listed: B12: 500–1,000 mcg, B6: 20–50 mg, Folate: 800 mcg daily | Reduce homocysteine levels, support neurotransmitter synthesis, and slow brain atrophy
| Grade C for Cognitive Decline500 people | ||
Confirmed studies for B Vitamins (B6, B12, Folate) (titles as PubMed lists them) | |||||
| Lion's Mane Mushroom | Amount listed: 500–3,000 mg daily | Stimulates nerve growth factor (NGF) production, supporting neurogenesis and myelin formation
| Not graded yet | ||
Confirmed studies for Lion's Mane Mushroom (titles as PubMed lists them) | |||||
Shop the evidence-backed picks
Support alongside medical care. These supplements are not a treatment for Mild Cognitive Impairment (MCI). If you are being treated for it, talk to your clinician before adding one: supplements can interact with medicines.
The collection holds the supplements we grade A or B for its theme, in third-party tested products where the catalog has them. It opens in our Fullscript store. You can look through it without signing in; Fullscript asks for a free account to order.
Or shop one supplement
Each opens third-party tested products, matched to the dose above where we can.
- Grade C
- Grade C
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How this protocol works
In plain language
Mild Cognitive Impairment (MCI) is the stage between normal age-related cognitive changes and dementia. People with MCI have noticeable memory or thinking problems that don't yet interfere with daily life. About 10-15% of people with MCI progress to dementia each year. Supporting brain health during this stage may slow decline.
- Omega-3 DHA makes up about 15% of brain fatty acids and is critical for neuron structure and function. DHA deficiency is associated with cognitive decline, and supplementation may improve memory and processing speed in people with MCI. Higher DHA intake is associated with reduced dementia risk.
- Phosphatidylserine is a phospholipid that makes up 15% of brain phospholipids. It's essential for cell membrane fluidity, neurotransmitter release, and cell signaling. Studies show improvements in memory, learning, and concentration.
- B Vitamins (B6, B12, Folate) are crucial for lowering homocysteine—an amino acid that at high levels damages blood vessels and neurons. The VITACOG trial showed that B vitamins slowed brain shrinkage by 30% in people with MCI who had elevated homocysteine. The effect was strongest in those with adequate omega-3 status.
- Lion's Mane Mushroom is unique in that it stimulates the production of Nerve Growth Factor (NGF), which supports the survival and growth of neurons. Japanese studies show improved cognitive function in older adults with MCI.
Expected timeline: Phosphatidylserine may show benefits within 4-6 weeks. DHA requires 3-6 months for brain incorporation. B vitamin effects on homocysteine occur within weeks; brain atrophy slowing requires longer observation.