Protocol · Immune
Lupus Nephritis Protocol
Vitamin D3 and Omega-3 Fatty Acids are the core of this stack, with 2 supporting supplements. Each row gives the amount the protocol lists and the grade our evidence database holds for that supplement in Lupus Nephritis.
We are re-verifying the studies cited on protocol pages; only confirmed citations are shown.
The stack
4 supplements · none graded yet
| Grade | Supplement | Amount listed | Why it’s in the stack | Evidence on file | Shop |
|---|---|---|---|---|---|
| Primary stackThe core of this protocol | |||||
| Vitamin D3 | Amount listed: 2,000–4,000 IU daily (higher with deficiency) | Immunomodulatory effects; deficiency strongly associated with lupus activity and nephritis risk | Not graded yet | ||
| Omega-3 Fatty Acids | Amount listed: 3–4 g EPA/DHA daily | Reduces inflammatory cytokines and may improve renal function markers | Not graded yet | ||
| Supporting stackListed as additions to the core | |||||
| N-Acetyl Cysteine (NAC) | Amount listed: 1,200–2,400 mg daily | Replenishes glutathione, reduces oxidative stress; may improve lupus disease activity | Not graded yet | ||
| Curcumin (with piperine) | Amount listed: 500 mg twice daily | Inhibits NF-κB and reduces autoantibody production in animal models | Not graded yet | ||
Shop this protocol
Support alongside medical care. These supplements are not a treatment for Lupus Nephritis. If you are being treated for it, talk to your clinician before adding one: supplements can interact with medicines.
Each opens third-party tested products, matched to the dose above where we can.
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How this protocol works
In plain language
Lupus nephritis is kidney inflammation caused by the autoimmune disease lupus, where the immune system attacks the body's own tissues. This protocol supports immune modulation and reduces inflammation.
- Vitamin D deficiency is extremely common in lupus (up to 75% of patients) and is associated with worse kidney involvement. Vitamin D has immunomodulatory effects—it can help calm the overactive immune response without suppressing immunity to infections.
- Omega-3s reduce the production of inflammatory molecules that damage kidney tissue. Studies show improved proteinuria (protein in urine) and kidney function markers.
- NAC replenishes glutathione, the body's master antioxidant, which is depleted in lupus. It may help reduce disease activity scores.
- Curcumin has anti-inflammatory effects through NF-κB inhibition and has shown promise in lupus animal models.
Critical note: Lupus nephritis is a serious condition requiring immunosuppressive medications under rheumatology/nephrology care. These supplements are adjunctive only—never replace prescribed treatments.
Expected timeline: Vitamin D repletion over 8-12 weeks. Anti-inflammatory effects may be noticed over 2-3 months. Always monitor kidney function with your doctor.