Protocol · Endocrine & Metabolic
Hypoadrenalism (Adrenal Insufficiency) Supportive Care Protocol
Vitamin C and Vitamin B5 (Pantothenic Acid) are the core of this stack, with 6 supporting supplements. Each row gives the amount the protocol lists and the grade our evidence database holds for that supplement in Hypoadrenalism (Adrenal Insufficiency) Supportive Care.
We are re-verifying the studies cited on protocol pages; only confirmed citations are shown.
The stack
8 supplements · 1 graded
| Grade | Supplement | Amount listed | Why it’s in the stack | Evidence on file |
|---|---|---|---|---|
| Primary stackThe core of this protocol | ||||
| Vitamin C | Amount listed: 500–1,000 mg daily in divided doses | Adrenal glands have highest vitamin C concentration; essential for cortisol and catecholamine synthesis | Not graded yet | |
| Vitamin B5 (Pantothenic Acid) | Amount listed: 500–1,000 mg daily | Essential for synthesis of coenzyme A and steroid hormones in adrenal glands | Not graded yet | |
| Supporting stackListed as additions to the core | ||||
| DHEA | Amount listed: 25–50 mg daily (women); 50–100 mg daily (men) - under medical supervision | Adrenal androgen often deficient in adrenal insufficiency; may improve quality of life
| Grade D for Body Fat20 people | |
| Licorice Root | Amount listed: 200–400 mg standardized extract daily (short-term only; medical supervision required) | Inhibits cortisol breakdown (11β-HSD); may extend cortisol action (use with caution) | Not graded yet | |
| Magnesium | Amount listed: 300–400 mg daily | Often depleted in adrenal insufficiency; supports energy production and stress response | Not graded yet | |
| Vitamin B6 | Amount listed: 50–100 mg daily | Supports neurotransmitter synthesis and adrenal function | Not graded yet | |
| Sodium/Salt | Amount listed: Liberal salt intake (3–4 g sodium daily) if mineralocorticoid-deficient | Primary adrenal insufficiency causes salt wasting; adequate sodium intake critical | Not graded yet | |
| Adaptogenic Herbs (Rhodiola/Eleuthero) | Amount listed: Rhodiola: 200–400 mg daily; Eleuthero: 300–400 mg daily | May support HPA axis adaptation to stress; adjunctive support only | Not graded yet | |
How this protocol works
In plain language
Hypoadrenalism (adrenal insufficiency) occurs when the adrenal glands don't produce enough hormones, particularly cortisol. Primary adrenal insufficiency (Addison's disease) involves damage to the adrenal glands themselves, while secondary adrenal insufficiency results from pituitary problems affecting ACTH (the hormone that stimulates the adrenals). Symptoms include severe fatigue, weight loss, low blood pressure, dizziness, salt cravings, hyperpigmentation (in primary), nausea, and weakness. Without treatment, adrenal crisis can be life-threatening.
CRITICAL: Adrenal insufficiency is a serious medical condition requiring hormone replacement therapy (hydrocortisone/cortisol replacement, and fludrocortisone for primary AI). This is NOT optional - it is life-sustaining treatment. Patients must wear medical alert identification, understand sick-day rules (increasing dose during illness/stress), carry emergency injection kits, and know signs of adrenal crisis. NO supplement can replace cortisol. These supplements support overall adrenal health but are ADJUNCTIVE to medical treatment. Never adjust steroid doses based on supplements or stop medication.
Vitamin C* is found in very high concentrations in the adrenal glands and is essential for synthesizing cortisol and catecholamines. Adequate intake supports remaining adrenal function.
Vitamin B5 (Pantothenic Acid)* is critical for producing coenzyme A, which is necessary for steroid hormone synthesis.
DHEA* is an adrenal androgen that is often deficient in adrenal insufficiency but not replaced by standard therapy. Studies show DHEA replacement can improve energy, mood, and quality of life, especially in women. Requires medical supervision.
Licorice Root* inhibits the enzyme that breaks down cortisol, potentially extending its effects. Use with extreme caution and only under medical supervision - can cause hypertension and hypokalemia.
Magnesium* supports energy production and is often depleted during stress.
Sodium/Salt* - Primary adrenal insufficiency causes aldosterone deficiency and salt wasting. Liberal salt intake is important, especially in hot weather or with exercise.
Adaptogenic herbs* may provide additional stress support but cannot replace hormone therapy.
Expected timeline: Hormone replacement provides benefit within days. DHEA effects may take 3-6 months to fully assess. Supplements support ongoing wellness.