Protocol · Sexual Health/Mental Health
Hypoactive Sexual Desire Disorder Support Protocol
Maca Root and DHEA are the core of this stack, with 4 supporting supplements. Each row gives the amount the protocol lists and the grade our evidence database holds for that supplement in Hypoactive Sexual Desire Disorder Support.
We are re-verifying the studies cited on protocol pages; only confirmed citations are shown.
The stack
6 supplements · 1 graded
| Grade | Supplement | Amount listed | Why it’s in the stack | Evidence on file | Shop |
|---|---|---|---|---|---|
| Primary stackThe core of this protocol | |||||
| Maca Root | Amount listed: 1.5–3 g daily | Traditional adaptogen; may improve sexual desire in both men and women | Not graded yet | ||
| DHEA | Amount listed: 25–50 mg daily (under medical supervision) | Precursor to sex hormones; may help if levels are low (especially in women) | Not graded yet | ||
| Supporting stackListed as additions to the core | |||||
| L-Arginine | Amount listed: 2.5–5 g daily | Nitric oxide precursor; supports blood flow to genital area | Not graded yet | ||
| Ginkgo Biloba | Amount listed: 120–240 mg daily | Improves circulation; may help with antidepressant-induced sexual dysfunction | Not graded yet | ||
| Tribulus Terrestris | Amount listed: 250–750 mg daily | Traditional use for libido; limited evidence but some positive trials in women
| Grade C for Erections4 studies · 180 people | ||
| Ashwagandha | Amount listed: 300–600 mg daily (standardized extract) | Adaptogen; may reduce stress and improve sexual function | Not graded yet | ||
Shop the evidence-backed picks
The collection holds the supplements we grade A or B for its theme, in third-party tested products where the catalog has them. It opens in our Fullscript store. You can look through it without signing in; Fullscript asks for a free account to order.
Or shop one supplement
Each opens third-party tested products, matched to the dose above where we can.
- Grade C
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How this protocol works
In plain language
Hypoactive Sexual Desire Disorder (HSDD) is characterized by persistently low sexual desire that causes personal distress. It can affect both men and women, though it's more commonly diagnosed in women.
KEY FEATURES:
- Absent or reduced sexual desire
- Causes personal distress or relationship difficulties
- Not explained by other conditions, medications, or relationship issues
- Present for at least 6 months
CONTRIBUTING FACTORS:
- Hormonal: Low testosterone, menopause, thyroid disorders
- Psychological: Depression, anxiety, stress, past trauma
- Relationship: Communication issues, conflict, lack of intimacy
- Medical: Chronic illness, fatigue, pain conditions
- Medications: Antidepressants (common), birth control, blood pressure meds
IMPORTANT: HSDD benefits from comprehensive evaluation and often psychological support. This protocol is SUPPORTIVE ONLY.
MEDICAL TREATMENTS:
- Women: Flibanserin (Addyi), bremelanotide (Vyleesi) - FDA approved
- Women (postmenopausal): May consider testosterone (off-label)
- Men: Testosterone replacement if low
- Both: Treat underlying conditions, adjust medications
NON-MEDICATION APPROACHES:
- Sex therapy/couples counseling
- Mindfulness and stress reduction
- Address relationship issues
- Exercise (improves mood and body image)
- Adequate sleep
- Limit alcohol
Maca and DHEA* have the most evidence for improving desire.
Adaptogens* may help if stress is a factor.
Address underlying causes* first.
Expected timeline: Supplements may show benefit within 4-8 weeks. Comprehensive treatment including psychological factors often more effective.