Protocol · Neurological
Dementia & Cognitive Decline Protocol
Omega-3 DHA and Phosphatidylserine are the core of this stack, with 4 supporting supplements. Each row gives the amount the protocol lists and the grade our evidence database holds for that supplement in Dementia & Cognitive Decline.
We are re-verifying the studies cited on protocol pages; only confirmed citations are shown.
The stack
6 supplements · 1 graded · 2 confirmed studies
| Grade | Supplement | Amount listed | Why it’s in the stack | Evidence on file | Shop |
|---|---|---|---|---|---|
| Primary stackThe core of this protocol | |||||
| Omega-3 DHA | Amount listed: 1,000–2,000 mg DHA daily | Primary structural fatty acid in brain; supports neuronal membrane integrity and reduces neuroinflammation | Not graded yet | ||
| Phosphatidylserine | Amount listed: 300 mg daily | Membrane phospholipid that supports neurotransmitter function and neuronal signaling
| Not graded yet | ||
Confirmed studies for Phosphatidylserine (titles as PubMed lists them) | |||||
| Supporting stackListed as additions to the core | |||||
| Lion's Mane Mushroom | Amount listed: 1,000–3,000 mg daily | Contains hericenones and erinacines that stimulate nerve growth factor (NGF) synthesis | Not graded yet | ||
Confirmed studies for Lion's Mane Mushroom (titles as PubMed lists them) | |||||
| Citicoline (CDP-Choline) | Amount listed: 500–1,000 mg daily | Provides choline for acetylcholine synthesis and supports phosphatidylcholine production | Not graded yet | ||
| Bacopa Monnieri | Amount listed: 300–450 mg daily (standardized to 50% bacosides) | Adaptogenic herb that enhances synaptic communication and has antioxidant effects | Not graded yet | ||
| Vitamin E (mixed tocopherols) | Amount listed: 400–800 IU daily | Antioxidant that protects brain lipids from oxidation; may slow functional decline
| Grade D for Alzheimer's Disease Risk3 studies · 820 people | ||
Shop the evidence-backed picks
Support alongside medical care. These supplements are not a treatment for Dementia & Cognitive Decline. If you are being treated for it, talk to your clinician before adding one: supplements can interact with medicines.
The collection holds the supplements we grade A or B for its theme, in third-party tested products where the catalog has them. It opens in our Fullscript store. You can look through it without signing in; Fullscript asks for a free account to order.
Or shop one supplement
Each opens third-party tested products, matched to the dose above where we can.
- Grade D
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How this protocol works
In plain language
Dementia involves progressive loss of brain cells and connections due to factors like oxidative stress, inflammation, and reduced blood flow. While no supplement can cure dementia, several may support brain health and potentially slow decline.
- DHA (omega-3) makes up 40% of brain fatty acids. Studies show people with higher DHA levels have slower cognitive decline. It reduces neuroinflammation and supports synaptic function.
- Phosphatidylserine is a key component of brain cell membranes. It supports neurotransmitter systems and cell-to-cell communication. Multiple studies show modest cognitive benefits.
- Lion's mane mushroom contains compounds that stimulate nerve growth factor (NGF), which supports neuron survival and growth. A Japanese study showed significant cognitive improvement in mild cognitive impairment.
- Citicoline provides building blocks for both acetylcholine (memory neurotransmitter) and brain cell membranes. It has decades of research in cognitive support.
- Bacopa is an Ayurvedic herb that enhances memory and learning, likely through antioxidant effects and enhanced nerve signaling.
- Vitamin E protects brain fats from oxidation. The TEAM-AD study showed it slowed functional decline in mild-moderate Alzheimer's.
Important: Supplements cannot reverse established dementia. Work with a neurologist for comprehensive care.
Expected timeline: Cognitive supplements typically require 3-6 months for noticeable effects.