Protocol · Oncology
Breast Cancer (Supportive Care) Protocol
Vitamin D and Turkey Tail Mushroom (PSK) are the core of this stack, with 2 supporting supplements. Each row gives the amount the protocol lists and the grade our evidence database holds for that supplement in Breast Cancer (Supportive Care).
We are re-verifying the studies cited on protocol pages; only confirmed citations are shown.
The stack
4 supplements · 3 graded
| Grade | Supplement | Amount listed | Why it’s in the stack | Evidence on file |
|---|---|---|---|---|
| Primary stackThe core of this protocol | ||||
| Vitamin D | Amount listed: 2,000–4,000 IU daily (titrate to 40–60 ng/mL) | Promotes cell differentiation, induces apoptosis in cancer cells, and modulates immune surveillance
| Grade C for Aromatase-Inhibitor Related Joint Pain1 study · 60 people | |
| Turkey Tail Mushroom (PSK) | Amount listed: 3 g daily | Beta-glucans activate NK cells and macrophages, supporting immune function during treatment
| Grade C for Lymphocyte Count9 people | |
| Supporting stackListed as additions to the core | ||||
| Omega-3 Fatty Acids | Amount listed: 2–4 g EPA/DHA daily | May improve chemotherapy efficacy, reduce treatment-related weight loss, and decrease inflammation | Not graded yet | |
| Melatonin | Amount listed: 3–20 mg at bedtime | May enhance chemotherapy response, protect against treatment toxicity, and improve sleep quality
| Grade D for Breast Cancer Risk1 study · 863 people | |
How this protocol works
In plain language
This protocol is for supportive care during breast cancer treatment—it's designed to support the immune system, reduce treatment side effects, and potentially improve outcomes. These supplements should be used alongside, not instead of, conventional medical treatment. Always discuss with your oncologist before starting any supplements.
- Vitamin D deficiency is common in breast cancer patients and associated with worse outcomes. Vitamin D helps regulate cell growth and supports immune function. Multiple studies link higher vitamin D levels to better survival rates. Most oncologists now recommend maintaining adequate vitamin D status.
- Turkey Tail Mushroom (PSK/PSP) has been used in Japan alongside chemotherapy for decades. Its beta-glucans activate immune cells that fight cancer. Studies show it may improve survival when combined with standard treatment.
- Omega-3 fatty acids may help maintain weight and muscle mass during treatment, reduce inflammation, and possibly enhance chemotherapy effectiveness. They also support cardiovascular health during treatment.
- Melatonin can improve sleep (often disrupted during cancer treatment), may enhance chemotherapy response, and provides antioxidant protection to healthy cells.
Expected timeline: Vitamin D levels should be optimized over 2-3 months. Immune support from turkey tail develops over 4-8 weeks. Melatonin helps sleep immediately; other effects develop over weeks to months.
Important: Always inform your oncologist about supplements. Some may interact with treatments.