Condition
Opioid Use Disorder
Opioid use disorder is a long-term medical condition in which opioid use becomes a pattern that causes real distress and disrupts daily life, driven by lasting changes in the brain's reward and stress systems. Supplements such as NAC and omega-3 fatty acids have drawn the most interest for cravings and mood in recovery, but little research on them has been reviewed here so far. Any interest in them is early, and they are not a substitute for established medical care.
- Supplements studied
- 1
- Graded outcomes
- 0
- People studied
- 65
Evidence by supplement
- Strong
- Moderate
- Limited
- Very limited
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Opioid dependence symptoms | Improves (the measure goes down) | 1 study | 65 people | |||
Studies that measured opioid dependence symptoms | ||||||
The Opioid Use Disorder Supportive Care protocol
2 primary supplements · 4 supporting supplements
- NAC (N-Acetyl Cysteine)1,200–2,400 mg daily in divided doses
- Omega-3 Fatty Acids2–3 g EPA+DHA daily
Studies cited
9 studies from PubMed
- Herbal medicines as anxiolytics prior to third molar surgical extraction. A randomized controlled clinical trial.
- Effects of passiflora incarnata and midazolam for control of anxiety in patients undergoing dental extraction.
- Effects of Passiflora incarnata Linnaeus on polysomnographic sleep parameters in subjects with insomnia disorder: a double-blind randomized placebo-controlled study.
- Effects of Passion Flower Extract, as an Add-On Treatment to Sertraline, on Reaction Time in Patients with Generalized Anxiety Disorder: A Double-Blind Placebo-Controlled Study.
- Passionflower in the treatment of generalized anxiety: a pilot double-blind randomized controlled trial with oxazepam.
- Passiflora incarnata Linneaus as an anxiolytic before spinal anesthesia.
- Preoperative oral Passiflora incarnata reduces anxiety in ambulatory surgery patients: a double-blind, placebo-controlled study.
- A double-blind, placebo-controlled investigation of the effects of Passiflora incarnata (passionflower) herbal tea on subjective sleep quality.
- Passionflower in the treatment of opiates withdrawal: a double-blind randomized controlled trial.