Dr. Grey AI

General Health

Research on overall health status, systemic effects of interventions, and general well-being outcomes.

Quick Answer

What it is

Research on overall health status, systemic effects of interventions, and general well-being outcomes.

Key findings

  • Grade A: Systemic Toxicity (Tyrothricin)

Safety

  • SAFETY CONCERN: Systemic administration causes significant toxicity - hemolysis and nephrotoxicity.
  • Similar toxicity profile to component gramicidin.
ℹ️ Quick Facts

Quick Facts: General Health

  • Supplements Studied:1
1 supps · 1 outcomes

Detailed Outcomes

A
Systemic Toxicity
SAFETY CONCERN: Systemic administration causes significant toxicity - hemolysis and nephrotoxicity. Use restricted to topical and local applications. Similar toxicity profile to component gramicidin.
large↑Worsens

Research Citations (16)

Electrospun fibers loaded with antimicrobial peptides for treatment of wound infections.
(2022)
PMID: 36150615
Efficacy and safety of a triple active sore throat lozenge in the treatment of patients with acute pharyngitis: Results of a multi-centre, randomised, placebo-controlled, double-blind, parallel-group trial (DoriPha)
(2018)
PMID: 30329199
Tyrothricin--An underrated agent for the treatment of bacterial skin infections and superficial wounds?
(2016)
PMID: 27455547
Chitosan-Based Film of Tyrothricin for Enhanced Antimicrobial Activity against Common Skin Pathogens Including Staphylococcus aureus.
(2016)
PMID: 26907760
Reduction of Inflammatory and Noninflammatory Lesions with Topical Tyrothricin 0.1% in the Treatment of Mild to Severe Acne Papulopustulosa: A Randomized Controlled Clinical Trial.
(2016)
PMID: 26458265
Decade-long use of the antimicrobial peptide combination tyrothricin does not pose a major risk of acquired resistance with gram-positive bacteria and Candida spp
(2015)
PMID: 25985581
Inhibition of malaria parasite blood stages by tyrocidines, membrane-active cyclic peptide antibiotics from Bacillus brevis
(2007)
PMID: 17462586
Tyrocidine B and gramicidin S. Structure and antibacterial action
(1992)
PMID: 1391687
Antibiotics and endodontics.
(1990)
PMID: 2090089
In vitro antibacterial activity of gramicidin and tyrothricin.
(1983)
PMID: 6199032

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Skin Health

1 shared supplement · 110 outcomes

Skin health refers to the integrity of skin function. Healthy skin maintains a barrier between the external environment and the inside of the body, and is characterized as smooth, moisturized, clear of blemishes, and radiant.

Respiratory Health

1 shared supplement · 20 outcomes

This goal refers to lung and breathing function in healthy people, not within the context of a related health condition.