Protocol · Urological Health
Cystitis (Bladder Infection) Prevention and Support Protocol
D-Mannose and Cranberry (Proanthocyanidins) are the core of this stack, with 4 supporting supplements. Each row gives the amount the protocol lists and the grade our evidence database holds for that supplement in Cystitis (Bladder Infection) Prevention and Support.
We are re-verifying the studies cited on protocol pages; only confirmed citations are shown.
The stack
6 supplements · none graded yet
| Grade | Supplement | Amount listed | Why it’s in the stack | Evidence on file | Shop |
|---|---|---|---|---|---|
| Primary stackThe core of this protocol | |||||
| D-Mannose | Amount listed: 1.5–2 g daily for prevention; 2 g every 2–3 hours for acute (with antibiotics) | Prevents E. coli from adhering to bladder wall; strong evidence for UTI prevention | Not graded yet | ||
| Cranberry (Proanthocyanidins) | Amount listed: 36 mg PAC (proanthocyanidins) daily or 400–500 mg cranberry extract | Prevents bacterial adhesion to bladder; long-standing evidence for UTI prevention | Not graded yet | ||
| Supporting stackListed as additions to the core | |||||
| Probiotics (Lactobacillus) | Amount listed: 1–10 billion CFU Lactobacillus rhamnosus GR-1 and L. reuteri RC-14 daily | Supports vaginal flora; may prevent UTI by maintaining healthy microbial balance | Not graded yet | ||
| Vitamin C | Amount listed: 500–1,000 mg daily | Acidifies urine; may help prevent bacterial growth | Not graded yet | ||
| Uva Ursi (Bearberry) | Amount listed: 400–800 mg standardized extract for short-term use (max 1–2 weeks) | Traditional remedy with antimicrobial properties; short-term use only | Not graded yet | ||
| Vitamin D | Amount listed: 2,000–4,000 IU daily | Supports immune function and antimicrobial peptide production in bladder | Not graded yet | ||
Shop this protocol
Each opens third-party tested products, matched to the dose above where we can.
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How this protocol works
In plain language
Cystitis is inflammation of the bladder, usually caused by a bacterial infection (urinary tract infection or UTI). It's very common, especially in women, with about 50% of women experiencing at least one UTI in their lifetime.
SYMPTOMS of cystitis:
- Burning sensation when urinating
- Frequent urge to urinate
- Passing small amounts of urine
- Cloudy or strong-smelling urine
- Blood in urine
- Pelvic discomfort
- Low-grade fever
RISK FACTORS:
- Female anatomy (short urethra)
- Sexual activity
- Menopause
- Urinary retention
- Catheter use
- Diabetes
CRITICAL: Acute cystitis typically requires antibiotic treatment. See a doctor for proper diagnosis and treatment.
WHEN TO SEEK IMMEDIATE CARE:
- Fever or chills
- Back or side pain (may indicate kidney infection)
- Nausea or vomiting
- Blood in urine
- Symptoms not improving with antibiotics
PREVENTION STRATEGIES:
- Drink plenty of fluids
- Urinate frequently (don't hold it)
- Wipe front to back
- Urinate after sexual activity
- Avoid irritating products
D-Mannose* has strong evidence for preventing recurrent UTIs - it prevents E. coli from sticking to the bladder wall.
Cranberry* products with adequate PACs (proanthocyanidins) may help prevent recurrence.
Probiotics* (specific Lactobacillus strains) support healthy urogenital flora.
Expected timeline: Acute symptoms typically improve within 1-3 days of starting antibiotics. Prevention supplements should be taken ongoing for those with recurrent infections.