Pasireotide (Signifor)
PeptidePasireotide is a novel multi-receptor-targeted somatostatin analog with high affinity for somatostatin receptor subtypes 1, 2, 3, and 5. FDA-approved in 2012, it is the first pituitary-directed medication for Cushing's disease. Available as twice-daily subcutaneous injection (Signifor) and long-acting monthly injection (Signifor LAR) for acromegaly. The Phase III PASPORT trial demonstrated significant urinary free cortisol normalization in Cushing's disease patients.
Quick Answer
What it is
Pasireotide is a novel multi-receptor-targeted somatostatin analog with high affinity for somatostatin receptor subtypes 1, 2, 3, and 5. FDA-approved in 2012, it is the first pituitary-directed medication for Cushing's disease.
Key findings
- Grade A: Urinary Free Cortisol Normalization (Cushing's Disease)
- Grade A: ACTH Secretion (Cushing's Disease)
- Grade A: Cushing's Disease Symptoms (Cushing's Disease)
Safety
No specific caution or interaction language was detected in the current summary/outcome notes.
⚠️ Research Notice
This peptide information is for educational and research purposes only. Peptides may not be FDA-approved for human use and may only be legally available for research purposes. Consult qualified healthcare professionals before considering any peptide compounds.
ℹ️ Quick Facts: Pasireotide (Signifor)
Quick Facts: Pasireotide (Signifor)
- Best Evidence:Grade A
- Conditions Studied:2
- Research Outcomes:10
- Grade A Findings:5
- Grade B Findings:1
- Key Effect:Cushing's Disease
Detailed Outcomes
Evidence by Condition
Research Citations (47)
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