Cushing's Disease
Research on Cushing's disease, a condition caused by excess cortisol production typically due to a pituitary adenoma secreting ACTH. Studies evaluate urinary free cortisol normalization, ACTH suppression, and clinical symptom improvement.
Quick Answer
What it is
Research on Cushing's disease, a condition caused by excess cortisol production typically due to a pituitary adenoma secreting ACTH. Studies evaluate urinary free cortisol normalization, ACTH suppression, and clinical symptom improvement.
Key findings
- Grade A: Urinary Free Cortisol Normalization (Pasireotide (Signifor))
- Grade A: ACTH Secretion (Pasireotide (Signifor))
- Grade A: Cushing's Disease Symptoms (Pasireotide (Signifor))
Safety
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ℹ️ Quick Facts
Quick Facts: Cushing's Disease
- Supplements Studied:1
1 supps · 3 outcomes
Detailed Outcomes
A
Urinary Free Cortisol Normalization
Phase III: 25% achieved UFC normalization at 6 months. 76% showed UFC decrease. Rapid reduction within 1-2 months, sustained up to 24 months.
large↓Improves
A
ACTH Secretion
Direct inhibition of ACTH release from corticotroph adenomas. Phase II showed decreased ACTH in majority of patients within 15 days.
large↓Improves
A
Cushing's Disease Symptoms
Improvements in clinical signs including weight, blood pressure, and metabolic parameters maintained over 24 months of treatment.
moderate↓Improves