Dr. Grey AI

Endometrial Cancer

Endometrial cancer is a condition in which cells in the endometrium (the inner lining of the uterus) start to grow out of control. It is the most common type of cancer in the uterus. The most frequent symptom is abnormal bleeding between periods or after menopause.

Quick Answer

What it is

Endometrial cancer is a condition in which cells in the endometrium (the inner lining of the uterus) start to grow out of control. It is the most common type of cancer in the uterus.

Key findings

No graded findings are available yet.

Safety

No specific caution or interaction language was detected in the current summary/outcome notes.

ℹ️ Quick Facts

Quick Facts: Endometrial Cancer

  • Supplements Studied:0
  • Research Trials:1
  • Total Participants:791
1 trials
791 ppts
0 supps · 0 outcomes

Evidence-Based Protocol

Supplement stack ranked by research quality

Limited Evidence

Primary Stack (Tier 1)

Vitamin DC
2000-4000 IU daily (maintain adequate levels)

Supports immune function; deficiency associated with worse outcomes; may affect cell differentiation

12 studies | 1,500 participants
Omega-3 Fatty AcidsC
2-3g EPA+DHA daily

Anti-inflammatory; may help preserve muscle mass during treatment

10 studies | 800 participants

Supporting Stack (Tier 2)

Protein SupplementsB
1.2-1.5g protein/kg body weight daily

Supports nutrition and muscle maintenance during cancer treatment

15 studies | 1,200 participants
CurcuminC
500-2000mg daily with enhanced absorption

Anti-inflammatory; laboratory studies show effects on endometrial cancer cells; may help with treatment side effects

6 studies | 300 participants
Green Tea ExtractC
300-500mg EGCG daily

EGCG has anti-cancer properties in laboratory studies; antioxidant effects

5 studies | 250 participants
ProbioticsC
10-20 billion CFU daily

Supports gut health during treatment; may help with treatment-related GI symptoms

8 studies | 400 participants
GingerB
250-1000mg daily around treatment

Helps with chemotherapy-induced nausea; anti-inflammatory

10 studies | 800 participants

How It Works

Endometrial cancer is cancer that begins in the lining of the uterus (endometrium). It is the most common gynecological cancer in developed countries, with most cases occurring after menopause.

TYPES:

•Type I (80-90%): Estrogen-dependent, typically endometrioid adenocarcinoma, usually better prognosis
•Type II (10-20%): Non-estrogen-dependent, includes serous and clear cell, more aggressive

RISK FACTORS:

•Obesity (major risk factor)
•Diabetes
•PCOS (polycystic ovary syndrome)
•Estrogen therapy without progesterone
•Tamoxifen use
•Nulliparity (never having given birth)
•Early menarche/late menopause
•Lynch syndrome (hereditary)

SYMPTOMS:

•Abnormal uterine bleeding (especially postmenopausal)
•Pelvic pain
•Pain during intercourse
•Unexplained weight loss (advanced)

CRITICAL: Endometrial cancer requires specialized gynecologic oncology care. This protocol is SUPPORTIVE ONLY.

TREATMENT:

•Surgery: Total hysterectomy with bilateral salpingo-oophorectomy (standard)
•Radiation: Vaginal brachytherapy and/or external beam
•Chemotherapy: For advanced or high-risk disease
•Hormone therapy: For select cases
•Immunotherapy: For MSI-high/dMMR tumors

NUTRITIONAL GOALS:

•Maintain healthy weight (obesity worsens outcomes)
•Support immune function
•Manage treatment side effects
•Adequate protein for healing

* Vitamin D supports immune function and is often deficient.

* Protein helps maintain muscle mass during treatment.

* Ginger may help with chemotherapy-induced nausea.

Expected timeline: Treatment is typically surgical with adjuvant therapy as needed. Supportive care continues through treatment and recovery.

Generated from peer-reviewed researchSchema v2.0