Dr. Grey AI

Pumpkin Seed Extract

Pumpkin seed extract is used for prostate health (BPH), hair loss, and overactive bladder. Contains phytosterols (beta-sitosterol), lignans, zinc, and delta-7-sterols. Mechanism involves 5-alpha reductase inhibition (like finasteride but weaker) and anti-androgen effects. Meta-analyses support modest benefit for BPH symptoms. One RCT showed hair growth benefit. Oil extract (Styrian pumpkin) commonly used. Generally safe with low side effect profile compared to pharmaceutical options.

Quick Answer

What it is

Pumpkin seed extract is used for prostate health (BPH), hair loss, and overactive bladder. Contains phytosterols (beta-sitosterol), lignans, zinc, and delta-7-sterols.

Key findings

  • Grade B: BPH Symptom Improvement
  • Grade C: Overactive Bladder Symptom Improvement
  • Grade C: Hair Growth

Safety

  • Generally safe with low side effect profile compared to pharmaceutical options.
ℹ️ Quick Facts: Pumpkin Seed Extract

Quick Facts: Pumpkin Seed Extract

  • Best Evidence:Grade B
  • Conditions Studied:0
  • Research Outcomes:3
  • Grade B Findings:1
Outcomes by grade:
A0
B1
C2
D0
0 conditions · 3 outcomes

Detailed Outcomes

B
BPH Symptom Improvement
Meta-analyses of multiple RCTs support modest improvement in IPSS (International Prostate Symptom Score) and urinary flow in men with BPH. Effect size is smaller than finasteride but with fewer side effects; often studied in combination with saw palmetto.
6 studies
moderate↑Improves
C
Overactive Bladder Symptom Improvement
Limited human studies suggest pumpkin seed extract may reduce overactive bladder symptoms, particularly in women. Proposed mechanism involves smooth muscle relaxation in the bladder wall.
3 studies
small↓Worsens
C
Hair Growth
A single 24-week RCT found that 400mg/day pumpkin seed oil increased hair count by approximately 40% compared to placebo, attributed to 5-alpha reductase inhibition. Promising but requires replication.
1 study
moderate↑Improves

You Might Also Like

Cucurbita pepo

1 shared outcome · 5 outcomes

Cucurbita pepo includes pumpkins, squash, zucchini, and gourds. Pumpkin seed oil and extracts are used primarily for prostate health (BPH) and urinary symptoms. Some human evidence supports benefits for BPH symptoms and overactive bladder, often in combination with saw palmetto. Contains phytosterols (beta-sitosterol), fatty acids, and zinc. Also studied for hair loss, diabetes, and parasites. The Styrian pumpkin seed oil is the most studied form.

China Rose

1 shared outcome · 4 outcomes

Hibiscus rosa-sinensis (China Rose) is distinct from Hibiscus sabdariffa (roselle/hibiscus tea). Traditionally used in Ayurveda for hair growth, stomach ulcers, and as an emmenagogue. Animal studies suggest antifertility, hair growth, antiulcer, and antioxidant effects. The flower contains anthocyanins, flavonoids, and mucilage. However, NO human clinical trials exist for any therapeutic use. Limited research interest compared to Hibiscus sabdariffa.