Dr. Grey AI

Methylliberine

Methylliberine (marketed as Dynamine) is a purine alkaloid found in coffee species (Coffea) and kucha tea. Structurally related to caffeine, it's marketed as providing caffeine-like energy and focus with fewer side effects (less jitters, better sleep compatibility). NO GRADED OUTCOMES - human research is extremely limited. The marketing claims outpace the evidence. May work synergistically with caffeine and theacrine. Novel stimulant with insufficient safety and efficacy data for confident recommendations.

Quick Answer

What it is

Methylliberine (marketed as Dynamine) is a purine alkaloid found in coffee species (Coffea) and kucha tea. Structurally related to caffeine, it's marketed as providing caffeine-like energy and focus with fewer side effects (less jitters, better sleep compatibility).

Key findings

  • Grade D: Mood, Energy, and Subjective Well-being
  • Grade D: Reaction Time and Vigilance

Safety

No specific caution or interaction language was detected in the current summary/outcome notes.

ℹ️ Quick Facts: Methylliberine

Quick Facts: Methylliberine

  • Best Evidence:Grade D
  • Conditions Studied:0
  • Research Outcomes:2
Outcomes by grade:
A0
B0
C0
D2
0 conditions · 2 outcomes

Detailed Outcomes

D
Mood, Energy, and Subjective Well-being
A small crossover trial (n=25) found 100 mg methylliberine alone improved self-reported mood (at 1, 2, and 3 hours), subjective concentration, motivation, and energy over 3 hours compared to placebo, though objective cognitive tests (Stroop, Trail Making Test-B) were unaffected. A separate crossover study (n=50) found a caffeine-methylliberine-theacrine combination increased self-reported alertness without increasing anxiety, unlike caffeine alone.
small↑Improves
D
Reaction Time and Vigilance
Two RCTs tested methylliberine only in combination with caffeine and theacrine. In male egamers (n=50), the combination improved Flanker Test inhibitory control and psychomotor vigilance reaction time. In tactical personnel (n=48), the combination improved reaction times comparably to caffeine alone (300 mg) at half the caffeine dose. Effects cannot be attributed to methylliberine independently.
small↑Improves