Supplement
Alpha-ketoglutarate is a molecule your cells make during the Krebs cycle, the process that turns food into energy, and it also helps move nitrogen and build amino acids. In one study, biological age estimated from DNA methylation came out about eight years lower, but the evidence is very limited. Only 42 people took part and there was no placebo group, so the result can't show the supplement caused it.
- Updated
- How we grade
- 4 studies cited
- Best evidence
- Grade D
- Conditions studied
- 1
- Outcomes
- 1
- Graded outcomes
- 0001
Evidence by condition
- Strong
- Moderate
- Limited
- Very limited
Biological Aging
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| DNA Methylation Age 8-year reduction in biological age (Rejuvant study, non-placebo-controlled) | Improves (the measure goes down) | Large effect | 42 people |
Key findings
- DNA Methylation AgeImproves (the measure goes down)
Shop Alpha-Ketoglutarate
Third-party tested Alpha-Ketoglutarate products. The evidence above is limited, so read it before you buy.
- Grade D
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Studies cited
4 studies from PubMed
- Alpha-ketoglutarate as a potent regulator for lifespan and healthspan: Evidences and perspectives
- Rejuvant, a potential life-extending compound formulation with alpha-ketoglutarate and vitamins, conferred an average 8 year reduction in biological aging
- Alpha-Ketoglutarate, an Endogenous Metabolite, Extends Lifespan and Compresses Morbidity in Aging Mice
- Alpha-Ketoglutarate as a Molecule with Pleiotropic Activity: Well-Known and Novel Possibilities of Therapeutic Use