Alpha-Ketoglutarate
Alpha-ketoglutarate (AKG) is an endogenous TCA cycle intermediate that regulates cellular energy production, protein synthesis via mTOR activation, and collagen formation as a cofactor for prolyl-4-hydroxylase. Mouse studies show CaAKG extends median lifespan 8-20% (females) and reduces frailty by 40%. One human study (Rejuvant, non-placebo-controlled) showed 8-year reduction in DNA methylation age. The ABLE RCT (1g CaAKG, n=120) is ongoing. AKG also detoxifies ammonia and supports bone/muscle health.
Quick Answer
What it is
Alpha-ketoglutarate (AKG) is an endogenous TCA cycle intermediate that regulates cellular energy production, protein synthesis via mTOR activation, and collagen formation as a cofactor for prolyl-4-hydroxylase. Mouse studies show CaAKG extends median lifespan 8-20% (females) and reduces frailty by 40%.
Key findings
- Grade D: DNA Methylation Age
Safety
No specific caution or interaction language was detected in the current summary/outcome notes.
ℹ️ Quick Facts: Alpha-Ketoglutarate
Quick Facts: Alpha-Ketoglutarate
- Best Evidence:Grade D
- Conditions Studied:0
- Research Outcomes:1