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Oxytocin (Pitocin)

Peptide

Oxytocin is a nonapeptide hormone. FDA-approved for labor induction and postpartum hemorrhage prevention. Cochrane review (61 studies, >12,000 women) confirms safety and efficacy. Reduces failure to deliver vaginally within 24h (8.4% vs 53.8% vs expectant management, RR 0.16). Standard of care for third stage of labor. Dosing: 0.5-20 mU/min IV for induction, 10 IU IM for PPH prevention.

Quick Answer

What it is

Oxytocin is a nonapeptide hormone. FDA-approved for labor induction and postpartum hemorrhage prevention.

Key findings

  • Grade A: Vaginal Delivery Success (Pregnancy and Delivery Health)
  • Grade A: Postpartum Hemorrhage Prevention (Pregnancy and Delivery Health)
  • Grade A: Labor Duration (Pregnancy and Delivery Health)

Safety

No specific caution or interaction language was detected in the current summary/outcome notes.

⚠️ Research Notice

This peptide information is for educational and research purposes only. Peptides may not be FDA-approved for human use and may only be legally available for research purposes. Consult qualified healthcare professionals before considering any peptide compounds.

ℹ️ Quick Facts: Oxytocin (Pitocin)

Quick Facts: Oxytocin (Pitocin)

  • Best Evidence:Grade A
  • Conditions Studied:1
  • Research Outcomes:8
  • Grade A Findings:4
  • Key Effect:Pregnancy and Delivery Health
A4
B0
C3
D1
1 conditions · 8 outcomes

Detailed Outcomes

A
Vaginal Delivery Success
Cochrane: 91.6% vaginal delivery within 24h vs 46.2% expectant management (RR 0.16 for failure). Effective labor induction agent.
large↑Improves
A
Postpartum Hemorrhage Prevention
Standard of care for PPH prophylaxis. High-dose protocols associated with lower PPH rates (7.6% vs 9.9%, RR 0.78).
large↓Worsens
A
Labor Duration
Reduces induction-to-delivery interval. High-dose vs low-dose shows shorter labor with high-dose regimens.
moderate↓Improves
A
Cesarean Rate
No significant difference in cesarean rates between high and low-dose protocols (~26-28%). Safe for labor management.
small↓Improves
C
Reproductive Outcomes
5 preclinical studies support this finding. Primarily preclinical evidence.
small↑Improves
C
Cognitive Function
4 systematic reviews and preclinical studies support this finding. Evidence includes systematic reviews/meta-analyses. Primarily preclinical evidence.
small↑Improves
C
Depression Symptoms
3 systematic reviews and preclinical studies support this finding. Evidence includes systematic reviews/meta-analyses. Primarily preclinical evidence.
small↓Improves
D
Liver Protection
2 preclinical studies support this finding. Primarily preclinical evidence.
small↑Improves