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Nesiritide (Natrecor)

Peptide

Nesiritide is a recombinant form of human B-type natriuretic peptide (BNP). FDA-approved in 2001 for acute decompensated heart failure (ADHF). Clinical trials in >2000 patients demonstrated rapid hemodynamic improvement and dyspnea relief. The VMAC trial showed superiority over nitroglycerin for dyspnea improvement. Administered as IV bolus followed by continuous infusion.

Quick Answer

What it is

Nesiritide is a recombinant form of human B-type natriuretic peptide (BNP). FDA-approved in 2001 for acute decompensated heart failure (ADHF).

Key findings

  • Grade A: Pulmonary Capillary Wedge Pressure (Heart Failure)
  • Grade A: Dyspnea Improvement (Heart Failure)
  • Grade A: Systemic Vascular Resistance (Heart Failure)

Safety

No specific caution or interaction language was detected in the current summary/outcome notes.

⚠️ Research Notice

This peptide information is for educational and research purposes only. Peptides may not be FDA-approved for human use and may only be legally available for research purposes. Consult qualified healthcare professionals before considering any peptide compounds.

ℹ️ Quick Facts: Nesiritide (Natrecor)

Quick Facts: Nesiritide (Natrecor)

  • Best Evidence:Grade A
  • Conditions Studied:1
  • Research Outcomes:12
  • Grade A Findings:4
  • Grade B Findings:4
  • Key Effect:Heart Failure
A4
B4
C2
D2
1 conditions · 12 outcomes

Detailed Outcomes

A
Pulmonary Capillary Wedge Pressure
Significant and sustained reduction in PCWP. VMAC trial showed greater PCWP reduction vs nitroglycerin at 3 hours (P=0.03).
large↓Improves
A
Dyspnea Improvement
VMAC trial: Greater improvement in dyspnea vs nitroglycerin at 3 hours. Rapid onset symptomatic relief in ADHF.
large↑Improves
A
Systemic Vascular Resistance
Balanced vasodilation with sustained SVR reduction without tachyphylaxis observed in clinical trials.
moderate↓Improves
A
Cardiac Output
Improved cardiac output secondary to afterload reduction. Comparable efficacy to dobutamine with better safety profile.
moderate↑Improves
B
Global Clinical Status
Improvement in global clinical status in trials, though long-term outcomes remain under study.
moderate↑Improves
B
Cardiac Protection
58 human trials and systematic reviews support this finding. Evidence includes systematic reviews/meta-analyses. Human clinical trial data available.
moderate↑Improves
B
Kidney Function
6 human trials and systematic reviews support this finding. Evidence includes systematic reviews/meta-analyses. Human clinical trial data available.
small↑Improves
B
Safety/Tolerability
5 human trials and systematic reviews support this finding. Evidence includes systematic reviews/meta-analyses. Human clinical trial data available.
small↑Improves
C
Mortality
4 human trials and systematic reviews support this finding. Evidence includes systematic reviews/meta-analyses. Human clinical trial data available.
small↓Improves
C
Cardiac Arrhythmia
3 preclinical studies support this finding. Primarily preclinical evidence.
small↓Improves
D
Pulmonary Function
2 preclinical studies support this finding. Primarily preclinical evidence.
small↑Improves
D
Muscle Mass/Function
2 preclinical studies support this finding. Primarily preclinical evidence.
small↑Improves

Research Citations (45)

B-Type Natriuretic Peptide Level for Atrial Fibrillation Ablation　- Is It a Wonderful Fortune Teller or a Mirror Reflecting Reality?
(2023)
PMID: 37899251
Serum NT-ProBNP potential marker of cirrhotic cardiomyopathy.
(2022)
PMID: 36876527
Natriuretic peptides and incident atrial fibrillation.
(2021)
PMID: 34600608
Nesiritide in patients with acute myocardial infarction and heart failure: a meta-analysis.
(2020)
PMID: 31948318
Admission NT-ProBNP in Myocardial Infarction: an Alert Sign?
(2019)
PMID: 31800689
Impact of Nesiritide Infusion on Early Postoperative Recovery After Total Cavopulmonary Connection Surgery.
(2018)
PMID: 29998377
Biomarkers to noninvasively determine the atrial fibrillation progression phenotype: A bridge to individualized ablative therapy?
(2018)
PMID: 29625276
Efficacy and safety of nesiritide in patients with decompensated heart failure: a meta-analysis of randomised trials.
(2016)
PMID: 26739721
Natriuretic peptides for the treatment of acute heart failure: a focus on nesiritide in recent clinical trials
(2015)
PMID: 26028173
The dose-dependent effect of nesiritide on renal function in patients with acute decompensated heart failure: a systematic review and meta-analysis of randomized controlled trials.
(2015)
PMID: 26107522