Abaloparatide
PeptideAbaloparatide (Tymlos) is an FDA-approved (2017) anabolic osteoporosis drug, NOT a supplement. It's a synthetic PTHrP analog that builds bone more effectively than older therapies. A-GRADE evidence for vertebral fracture reduction (86%), non-vertebral fractures (43%), and BMD increases. Requires daily subcutaneous injection. PRESCRIPTION ONLY - included here for informational purposes. Used in high-risk postmenopausal women and men. Has faster receptor kinetics than teriparatide with possibly better safety profile.
Quick Answer
What it is
Abaloparatide (Tymlos) is an FDA-approved (2017) anabolic osteoporosis drug, NOT a supplement. It's a synthetic PTHrP analog that builds bone more effectively than older therapies.
Key findings
- Grade A: Vertebral Fracture Risk (Osteoporosis)
- Grade A: Non-Vertebral Fracture Risk (Osteoporosis)
- Grade A: Lumbar Spine BMD (Osteoporosis)
Safety
- Used in high-risk postmenopausal women and men.
⚠️ Research Notice
This peptide information is for educational and research purposes only. Peptides may not be FDA-approved for human use and may only be legally available for research purposes. Consult qualified healthcare professionals before considering any peptide compounds.
ℹ️ Quick Facts: Abaloparatide
Quick Facts: Abaloparatide
- Best Evidence:Grade A
- Conditions Studied:1
- Research Outcomes:9
- Grade A Findings:5
- Grade B Findings:2
- Key Effect:Osteoporosis
Detailed Outcomes
Evidence by Condition
Research Citations (39)
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Peptide1 shared condition · 13 outcomes
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Romosozumab (Evenity)
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Romosozumab (Evenity) is a humanized monoclonal antibody that inhibits sclerostin, a key negative regulator of bone formation. FDA-approved in April 2019 for postmenopausal women with osteoporosis at high fracture risk. It has a unique dual mechanism: stimulating bone formation while reducing bone resorption. The FRAME and ARCH trials demonstrated significant reductions in vertebral and clinical fractures.
Denosumab (Prolia/Xgeva)
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Calcitonin Salmon
Peptide1 shared condition · 14 outcomes
Calcitonin salmon is a 32-amino acid peptide hormone analog used for postmenopausal osteoporosis and hypercalcemia. FDA-approved since 1975 as nasal spray (200 IU daily) and injection (100 IU daily). A-GRADE evidence: PROOF trial showed 33% reduction in vertebral fractures at 200 IU daily. A-GRADE for bone turnover marker reduction and acute fracture pain relief. B-GRADE for BMD increase and chronic bone pain. Has unique analgesic properties making it useful for acute osteoporotic fracture pain. Salmon calcitonin has 40-50x greater potency than human calcitonin. PRESCRIPTION ONLY - second-line osteoporosis treatment after bisphosphonates.