Cushing's Syndrome
A condition caused by prolonged exposure to high cortisol levels. ACTH-dependent forms include pituitary adenomas (Cushing's disease) and ectopic ACTH secretion. Diagnosis requires differentiating the source of excess ACTH, often using CRH stimulation testing.
Quick Answer
What it is
A condition caused by prolonged exposure to high cortisol levels. ACTH-dependent forms include pituitary adenomas (Cushing's disease) and ectopic ACTH secretion.
Key findings
- Grade A: Cushing's Disease Diagnosis (Corticorelin Ovine (Acthrel))
- Grade A: ACTH/Cortisol Response (Corticorelin Ovine (Acthrel))
- Grade A: Ectopic ACTH Exclusion (Corticorelin Ovine (Acthrel))
Safety
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ℹ️ Quick Facts
Quick Facts: Cushing's Syndrome
- Supplements Studied:1
1 supps · 3 outcomes
Detailed Outcomes
A
Cushing's Disease Diagnosis
CRH test sensitivity 86-93%, specificity 90-100% for Cushing's disease. 93/100 patients with Cushing's disease showed ≥35% ACTH increase, 0/16 with ectopic ACTH. Superior to dexamethasone suppression test (91% vs 75% accuracy).
large↑Improves
A
ACTH/Cortisol Response
Positive criteria: ≥35-40% ACTH increase and/or ≥20% cortisol increase. ≥40% cortisol increase most specific (PPV 99%). Peak response at 15-30 minutes. Absent response in ectopic ACTH syndrome.
large↑Worsens
A
Ectopic ACTH Exclusion
Ectopic ACTH tumors fail to respond to CRH stimulation. 0% of ectopic ACTH patients show positive response. False negative rate in Cushing's disease 5-10%. Ovine CRH preferred over human CRH for higher sensitivity.
large↑Improves